鲁索利替尼磷酸盐
- 价格： ￥28/千克
- 发布日期： 2020-06-09
- 更新日期： 2024-04-19
产品详请
| 产地 |
湖北
|
| 品牌 |
国产
|
| 用途 |
工业大生产
|
| 英文名称 |
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran
|
| CAS编号 |
1092939-17-7
|
| 别名 |
磷酸卢索替尼;鲁索替尼磷酸盐
|
| 纯度 |
98%
|
| 规格 |
25千克/桶
|
| 分子式 |
C17H18N6.H3PO4
|
用途一种有效的JAK1/2抑制剂,IC50分别为3.3nM/2.8nM，比JAK3选择性高130倍。RuxolitinibisanorallybioavailableJanus-associatedkinase(JAK)inhibitorwithpotentialantineoplasticandimmunomodulatingactivities.RuxolitinibspecificallybindstoandinhibitsproteintyrosinekinasesJAK1and2,whichmayleadtoareductionininflammationandaninhibitionofcellularpChemicalbookroliferation.TheJAK-STAT(signaltransducerandactivatoroftranscription)pathwayplaysakeyroleinthesignalingofmanycytokinesandgrowthfactorsandisinvolvedincellularproliferation,growth,hematopoiesis,andtheimmuneresponse;JAKkinasesmaybeupregulatedininflammatorydiseases,myeloproliferativedisorders,andvariousmalignancies.
